.Pharmacolibrary.Drugs.ATC.J.J05AF03

Information

name:Zalcitabine
ATC code:J05AF03
route:oral
n-compartments1

Zalcitabine is a nucleoside reverse transcriptase inhibitor (NRTI) formerly used in the treatment of HIV infection. It inhibits viral replication by interfering with reverse transcriptase activity. Due to toxicity concerns and the development of better alternatives, zalcitabine has been withdrawn from the market and is not currently approved for clinical use.

Pharmacokinetics

Pharmacokinetic parameters following oral administration in HIV-infected adult patients; typically studied population included males and females aged 18-60 with normal renal and hepatic function.

References

  1. Adams, JM, et al., & Morse, GD (1998). Zalcitabine population pharmacokinetics: application of radioimmunoassay. Antimicrobial agents and chemotherapy 42(2) 409–413. DOI:10.1128/AAC.42.2.409 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9527795

  2. Stretcher, BN (1995). Pharmacokinetic optimisation of antiretroviral therapy in patients with HIV infection. Clinical pharmacokinetics 29(1) 46–65. DOI:10.2165/00003088-199529010-00006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7586898

  3. Gustavson, LE, et al., & Dunton, AW (1990). A pilot study of the bioavailability and pharmacokinetics of 2',3'-dideoxycytidine in patients with AIDS or AIDS-related complex. Journal of acquired immune deficiency syndromes 3(1) 28–31. PUBMED:https://pubmed.ncbi.nlm.nih.gov/2152803

Revisions


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