.Pharmacolibrary.Drugs.ATC.J.J05AF08 .Pharmacolibrary.Drugs.ATC.J.J05AF08| name: | AdefovirDipivoxil |
| ATC code: | J05AF08 | route: | oral |
| n-compartments | 1 |
Adefovir dipivoxil is an oral nucleotide analog reverse transcriptase inhibitor formerly approved for the treatment of chronic hepatitis B virus (HBV) infection in adults. Due to risk of nephrotoxicity and availability of more effective treatments, its use has been largely discontinued in favor of safer alternatives. It works by inhibiting HBV polymerase, suppressing viral replication.
Pharmacokinetics in healthy adult male and female volunteers after oral administration. Parameters are based on published clinical pharmacokinetic studies.
Huang, J, et al., & Zheng, Q (2014). Population pharmacokinetics of adefovir dipivoxil tablets in healthy Chinese volunteers. International journal of clinical pharmacology and therapeutics 52(1) 8–14. DOI:10.5414/CP201928 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24219967
Fok, BS, et al., & Tomlinson, B (2013). Pharmacokinetic properties of single-dose lamivudine/adefovir dipivoxil fixed-dose combination in healthy Chinese male volunteers. Clinical therapeutics 35(1) 68–76. DOI:10.1016/j.clinthera.2012.12.001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23274144
Pfister, M, et al., & Sheiner, LB (2003). Population pharmacokinetics and pharmacodynamics of efavirenz, nelfinavir, and indinavir: Adult AIDS Clinical Trial Group Study 398. Antimicrobial agents and chemotherapy 47(1) 130–137. DOI:10.1128/AAC.47.1.130-137.2003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12499180