.Pharmacolibrary.Drugs.ATC.J.J05AJ01

Information

name:Raltegravir
ATC code:J05AJ01
route:oral
n-compartments2

Raltegravir is an antiretroviral medication used for the treatment of human immunodeficiency virus (HIV) infection. It is classified as an HIV integrase inhibitor and is approved for use in both treatment-naive and treatment-experienced adults, adolescents, and children.

Pharmacokinetics

Pharmacokinetics reported for healthy adult volunteers and HIV-infected patients following oral administration.

References

  1. Lommerse, J, et al., & Chain, A (2019). Maternal-Neonatal Raltegravir Population Pharmacokinetics Modeling: Implications for Initial Neonatal Dosing. CPT: pharmacometrics & systems pharmacology 8(9) 643–653. DOI:10.1002/psp4.12443 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31215170

  2. Dickinson, L, et al., & Boffito, M (2020). Population pharmacokinetics and pharmacogenetics of ritonavir-boosted darunavir in the presence of raltegravir or tenofovir disoproxil fumarate/emtricitabine in HIV-infected adults and the relationship with virological response: a sub-study of the NEAT001/ANRS143 randomized trial. The Journal of antimicrobial chemotherapy 75(3) 628–639. DOI:10.1093/jac/dkz479 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31754703

  3. Anderson, MS, et al., & Iwamoto, M (2011). Effect of raltegravir on estradiol and norgestimate plasma pharmacokinetics following oral contraceptive administration in healthy women. British journal of clinical pharmacology 71(4) 616–620. DOI:10.1111/j.1365-2125.2010.03885.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/21395656

Revisions


Generated at 2025-07-21T18:21:10Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos