.Pharmacolibrary.Drugs.ATC.J.J05AP55 .Pharmacolibrary.Drugs.ATC.J.J05AP55| name: | SofosbuvirAndVelpatasvir | |
| ATC code: | J05AP55 | route: | oral |
| compartments: | 2 | |
| dosage: | 400 | mg |
| volume of distribution: | 127 | L |
| clearance: | 68 | L/h |
| other parameters in model implementation | ||
Sofosbuvir and velpatasvir is a fixed-dose combination antiviral medication used for the treatment of chronic hepatitis C virus (HCV) infection in adults and children. Sofosbuvir is a nucleotide analog NS5B polymerase inhibitor, and velpatasvir is an NS5A inhibitor. The combination is approved and widely used globally as one of the standard regimens for pan-genotypic treatment of HCV.
PK parameters as reported in healthy adult volunteers following a single oral dose of the fixed-dose combination tablet (400 mg sofosbuvir/100 mg velpatasvir).