.Pharmacolibrary.Drugs.ATC.J.J05AR02

Information

name:LamivudineAndAbacavir
ATC code:J05AR02
route:oral
n-compartments1

Lamivudine and abacavir is a fixed-dose combination antiviral medication used in the treatment of HIV infection. Both drugs are nucleoside reverse transcriptase inhibitors (NRTIs) that inhibit viral replication by acting as chain terminators during reverse transcription. The combination is widely approved and recommended as part of antiretroviral therapy (ART) for adults, adolescents, and children with HIV.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult HIV-negative volunteers; fixed-dose combination tablet administered orally.

References

  1. Bouazza, N, et al., & Urien, S (2015). Lopinavir/ritonavir plus lamivudine and abacavir or zidovudine dose ratios for paediatric fixed-dose combinations. Antiviral therapy 20(2) 225–233. DOI:10.3851/IMP2876 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25279808

  2. Bouazza, N, et al., & Urien, S (2017). Optimization of the strength of the efavirenz/lamivudine/abacavir fixed-dose combination for paediatric patients. The Journal of antimicrobial chemotherapy 72(2) 490–495. DOI:10.1093/jac/dkw444 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27798221

  3. Kasirye, P, et al., & Walker, AS (2012). Pharmacokinetics of antiretroviral drug varies with formulation in the target population of children with HIV-1. Clinical pharmacology and therapeutics 91(2) 272–280. DOI:10.1038/clpt.2011.225 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22190066

Revisions


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