.Pharmacolibrary.Drugs.ATC.J.J05AR12

Information

name:LamivudineAndTenofovirDisoproxil
ATC code:J05AR12
route:oral
n-compartments1

Lamivudine and tenofovir disoproxil are antiretroviral medications used in combination for the treatment of HIV-1 infection in adults and adolescents, and also for chronic hepatitis B infection (tenofovir). Both drugs are approved and recommended as first-line therapy by major guidelines.

Pharmacokinetics

Population pharmacokinetic parameters from published studies of HIV-infected adults, both sexes, receiving oral fixed-dose combination tablets of lamivudine 300 mg and tenofovir disoproxil fumarate 300 mg once daily.

References

  1. Bednasz, CJ, et al., & Morse, GD (2019). Race/Ethnicity and Protease Inhibitor Use Influence Plasma Tenofovir Exposure in Adults Living with HIV-1 in AIDS Clinical Trials Group Study A5202. Antimicrobial agents and chemotherapy 63(4) –. DOI:10.1128/AAC.01638-18 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30642925

  2. De Sousa Mendes, M, et al., & Benaboud, S (2015). Physiologically-based pharmacokinetic modeling of renally excreted antiretroviral drugs in pregnant women. British journal of clinical pharmacology 80(5) 1031–1041. DOI:10.1111/bcp.12685 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26011128

Revisions


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