.Pharmacolibrary.Drugs.ATC.J.J05AR18

Information

name:EmtricitabineTenofovirAlafenamideElvitegravirAndCobicistat
ATC code:J05AR18
route:oral
n-compartments1

A fixed-dose combination antiretroviral medication containing emtricitabine, tenofovir alafenamide, elvitegravir and cobicistat, primarily used for the treatment of HIV-1 infection in adults and adolescents. It is approved and widely used as a single-tablet regimen for HIV management.

Pharmacokinetics

Steady-state pharmacokinetics in healthy adult subjects after oral administration of the fixed-dose combination tablet under fed conditions.

References

  1. Yamada, H, et al., & Irie, S (2018). Effects of a Nutritional Protein-Rich Drink on the Pharmacokinetics of Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Alafenamide, and Tenofovir Compared With a Standard Meal in Healthy Japanese Male Subjects. Clinical pharmacology in drug development 7(2) 132–142. DOI:10.1002/cpdd.365 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28581645

Revisions

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