.Pharmacolibrary.Drugs.ATC.J.J07CA12

Information

name:DiphtheriaPertussisPoliomyelitisTetanusHepatitisB
ATC code:J07CA12
route:intramuscular
n-compartments1

This is a combination vaccine used to protect against five serious diseases: diphtheria, pertussis (whooping cough), poliomyelitis, tetanus, and hepatitis B. It is administered primarily to infants and young children as a part of routine immunization schedules. The vaccine is approved and widely used in pediatric practice worldwide.

Pharmacokinetics

No published pharmacokinetic studies or compartmental PK models are available for the pentavalent diphtheria-pertussis-poliomyelitis-tetanus-hepatitis B combination vaccine. The vaccine is typically given as an intramuscular injection in infants and young children; classical pharmacokinetic parameters (such as systemic absorption rates, central volume of distribution, clearance) are not generally relevant or reported for vaccines.

References

  1. Zhu, Q, et al., & Suzich, JA (2017). A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants. Science translational medicine 9(388) –. DOI:10.1126/scitranslmed.aaj1928 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28469033

  2. Maese, L, et al., & Rau, RE (2023). Recombinant Erwinia asparaginase (JZP458) in acute lymphoblastic leukemia: results from the phase 2/3 AALL1931 study. Blood 141(7) 704–712. DOI:10.1182/blood.2022016923 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36108304

  3. Huang, CJ, et al., & Shih, KC (2023). Pharmacokinetics and Safety of Long-Acting Release Formulations of Pasireotide (SOM230) in a Male Population Who Are Hyperendemic Hepatitis B/C and Chronic Kidney Disease: An Open-Label, Phase I Study. European journal of drug metabolism and pharmacokinetics 48(6) 665–674. DOI:10.1007/s13318-023-00854-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37751056

Revisions


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