.Pharmacolibrary.Drugs.ATC.L.L01AB02_1

Information

name:Treosulfan_1
ATC code:L01AB02_1
route:intravenous
n-compartments2

Treosulfan is an alkylating agent used in conditioning regimens prior to hematopoietic stem cell transplantation (HSCT), mainly for treatment of hematological malignancies and some non-malignant diseases. It is currently approved and in clinical use in several countries for both adults and children as a part of preparative regimens for transplantation.

Pharmacokinetics

Pharmacokinetic parameters reported in pediatric patients undergoing hematopoietic stem cell transplantation receiving intravenous treosulfan. Mean values from a pediatric population PK model.

References

  1. Rosser, SPA, et al., & Nath, CE (2023). Evaluation of treosulfan cumulative exposure in paediatric patients through population pharmacokinetics and dosing simulations. British journal of clinical pharmacology 89(4) 1413–1424. DOI:10.1111/bcp.15599 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36369677

  2. Danielak, D, et al., & Główka, F (2018). Population pharmacokinetics of treosulfan and development of a limited sampling strategy in children prior to hematopoietic stem cell transplantation. European journal of clinical pharmacology 74(1) 79–89. DOI:10.1007/s00228-017-2344-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/28975382

  3. Li, X, et al., & Sykora, KW (2023). Population pharmacokinetic modeling of treosulfan and rationale for dose recommendation in children treated for conditioning prior to allogeneic hematopoietic stem cell transplantation. Drug metabolism and pharmacokinetics 52 100515–None. DOI:10.1016/j.dmpk.2023.100515 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37481830

Revisions


Generated at 2025-07-21T18:21:10Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos