.Pharmacolibrary.Drugs.ATC.L.L01AC01_1

Information

name:Thiotepa_1
ATC code:L01AC01_1
route:intravenous
n-compartments2

Thiotepa is an alkylating agent of the ethyleneimine type, used primarily as an antineoplastic chemotherapy drug. It has been indicated for use in the treatment of various cancers including breast cancer, ovarian cancer, and bladder cancer. Thiotepa is approved for use as a conditioning treatment prior to hematopoietic stem cell transplantation and for high-dose chemotherapy settings.

Pharmacokinetics

Pharmacokinetic parameters reported for pediatric patients undergoing stem cell transplantation using intravenous thiotepa.

References

  1. de Jonge, ME, et al., & Beijnen, JH (2005). Population pharmacokinetics of cyclophosphamide and its metabolites 4-hydroxycyclophosphamide, 2-dechloroethylcyclophosphamide, and phosphoramide mustard in a high-dose combination with Thiotepa and Carboplatin. Therapeutic drug monitoring 27(6) 756–765. DOI:10.1097/01.ftd.0000177224.19294.92 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16306851

  2. Huitema, AD, et al., & Beijnen, JH (2000). Validation of techniques for the prediction of carboplatin exposure: application of Bayesian methods. Clinical pharmacology and therapeutics 67(6) 621–630. DOI:10.1067/mcp.2000.106827 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10872644

  3. van Warmerdam, LJ, et al., & Beijnen, JH (1994). Validation of a limited sampling model for carboplatin in a high-dose chemotherapy combination. Cancer chemotherapy and pharmacology 35(2) 179–181. DOI:10.1007/BF00686644 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7987998

Revisions


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