.Pharmacolibrary.Drugs.ATC.L.L01AD04

Information

name:Streptozocin
ATC code:L01AD04
route:intravenous
n-compartments2

Streptozocin is an antineoplastic agent belonging to the nitrosourea class. It is specifically used for the treatment of pancreatic islet cell carcinoma (pancreatic neuroendocrine tumors). Streptozocin is an alkylating agent approved for clinical use but mainly reserved for rare tumors due to its toxicity profile.

Pharmacokinetics

Pharmacokinetic parameters observed in adult patients with metastatic islet cell carcinoma receiving intravenous infusion.

References

  1. Kim, YC, et al., & Lee, MG (2008). Pharmacokinetics of phenytoin and its metabolite, 4'-HPPH, after intravenous and oral administration of phenytoin to diabetic rats induced by alloxan or streptozotocin. Biopharmaceutics & drug disposition 29(1) 51–61. DOI:10.1002/bdd.591 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18022993

  2. Engler, FA, et al., & Balthasar, JP (2014). Investigation of the influence of nephropathy on monoclonal antibody disposition: a pharmacokinetic study in a mouse model of diabetic nephropathy. Pharmaceutical research 31(5) 1185–1193. DOI:10.1007/s11095-013-1241-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/24203494

  3. Chen, T, et al., & Mager, DE (2013). Population pharmacodynamic modeling of exenatide after 2-week treatment in STZ/NA diabetic rats. Journal of pharmaceutical sciences 102(10) 3844–3851. DOI:10.1002/jps.23682 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23897494

Revisions


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