.Pharmacolibrary.Drugs.ATC.L.L01BC52

Information

name:FluorouracilCombinations
ATC code:L01BC52
route:intravenous
compartments:2
dosage:500mg
volume of distribution:12.7L
clearance:1320mL/min
other parameters in model implementation

Fluorouracil (5-FU) is a pyrimidine analog and antimetabolite that interferes with DNA synthesis. It is commonly used as a chemotherapeutic agent for various solid tumors, including colorectal, breast, head and neck, and gastrointestinal cancers. In combinations, 5-FU is used with other cytostatic drugs to enhance therapeutic efficacy. Fluorouracil remains a standard treatment modality and is approved for use in multi-agent chemotherapy protocols.

Pharmacokinetics

Population pharmacokinetics of fluorouracil in adult cancer patients, both sexes, with various solid tumors, receiving fluorouracil in combination protocols as part of standard intravenous chemotherapy regimens.

References

    Revisions


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