.Pharmacolibrary.Drugs.ATC.L.L01CA02

Information

name:Vincristine
ATC code:L01CA02
route:intravenous
n-compartments3

Vincristine is a vinca alkaloid chemotherapeutic agent approved for use in the treatment of various malignancies including acute lymphoblastic leukemia, Hodgkin's lymphoma, non-Hodgkin's lymphoma, Wilms' tumor, neuroblastoma, and rhabdomyosarcoma. It is not used for solid tumors. Vincristine interferes with microtubule formation and mitosis.

Pharmacokinetics

Pharmacokinetic parameters reported for adult cancer patients; sex: both; typical intravenous dosing as a bolus.

References

  1. van de Velde, ME, et al., & Kaspers, GL (2020). Population Pharmacokinetics of Vincristine Related to Infusion Duration and Peripheral Neuropathy in Pediatric Oncology Patients. Cancers 12(7) –. DOI:10.3390/cancers12071789 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32635465

  2. Gota, V, et al., & Menon, H (2016). Population pharmacokinetics of Reditux™, a biosimilar Rituximab, in diffuse large B-cell lymphoma. Cancer chemotherapy and pharmacology 78(2) 353–359. DOI:10.1007/s00280-016-3083-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/27329361

  3. Davies, A, et al., & Macdonald, D (2014). Pharmacokinetics and safety of subcutaneous rituximab in follicular lymphoma (SABRINA): stage 1 analysis of a randomised phase 3 study. The Lancet. Oncology 15(3) 343–352. DOI:10.1016/S1470-2045(14)70005-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24521993

Revisions


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