.Pharmacolibrary.Drugs.ATC.L.L01CD02

Information

name:Docetaxel
ATC code:L01CD02
route:intravenous
n-compartments3

Docetaxel is a semisynthetic taxane antineoplastic agent used primarily for the treatment of various cancers including breast, non-small cell lung, prostate, gastric, and head and neck cancer. It acts by promoting and stabilizing microtubule assembly, thereby inhibiting mitosis and cell proliferation. It is an approved chemotherapy drug widely used today.

Pharmacokinetics

Pharmacokinetic parameters reported in adult cancer patients with normal hepatic function, following intravenous infusion.

References

  1. Paller, CJ, et al., & Levine, M (2024). High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial. Cancer research communications 4(8) 2174–2182. DOI:10.1158/2767-9764.CRC-24-0225 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39076107

  2. Ismael, G, et al., & Jackisch, C (2012). Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): a phase 3, open-label, multicentre, randomised trial. The Lancet. Oncology 13(9) 869–878. DOI:10.1016/S1470-2045(12)70329-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22884505

  3. Patil, A, et al., & Gota, V (2021). ADME gene polymorphisms do not influence the pharmacokinetics of docetaxel: Results from a population pharmacokinetic study in Indian cancer patients. Cancer medicine 10(14) 4948–4956. DOI:10.1002/cam4.4026 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34156160

Revisions


Generated at 2025-07-21T18:21:10Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos