.Pharmacolibrary.Drugs.ATC.L.L01CD04

Information

Cabazitaxel is a semisynthetic taxane antineoplastic agent used primarily for the treatment of metastatic castration-resistant prostate cancer. It works by inhibiting microtubule depolymerization, thereby resulting in cell cycle arrest and apoptosis in cancer cells. Cabazitaxel is approved for use, particularly in patients previously treated with docetaxel.

Pharmacokinetics

Pharmacokinetic parameters from adult cancer patients (predominantly male, median age ~68 years) receiving cabazitaxel 25 mg/m² as a 1-hour intravenous infusion.

References

1. Nozawa, M, et al., & Kakehi, Y (2015). Japanese phase I study of cabazitaxel in metastatic castration-resistant prostate cancer. International journal of clinical oncology 20(5) 1026–1034. DOI:10.1007/s10147-015-0820-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25809824

2. Valsalakumari, R, et al., & Iversen, TG (2024). Preclinical Efficacy of Cabazitaxel Loaded Poly(2-alkyl cyanoacrylate) Nanoparticle Variants. International journal of nanomedicine 19 3009–3029. DOI:10.2147/IJN.S450283 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38562610

3. Mukai, H, et al., & Suzuki, K (2014). Phase I dose-escalation and pharmacokinetic study (TED 11576) of cabazitaxel in Japanese patients with castration-resistant prostate cancer. Cancer chemotherapy and pharmacology 73(4) 703–710. DOI:10.1007/s00280-014-2394-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/24488323

Revisions

• 06/2025 initial generated model