name: | Topotecan_1 |
ATC code: | L01CE01_1 | route: | oral |
n-compartments | 2 |
Topotecan is a topoisomerase I inhibitor used primarily in the treatment of various cancers including ovarian cancer, small cell lung cancer, and cervical cancer. It is an antineoplastic agent that interferes with the replication of DNA in cancer cells. Topotecan is an approved drug and is administered commonly via intravenous infusion or orally.
Population pharmacokinetics in adult cancer patients following oral administration.
Roberts, JK, et al., & Stewart, CF (2016). Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant. Drug metabolism and disposition: the biological fate of chemicals 44(7) 1116–1122. DOI:10.1124/dmd.115.068676 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27052877
Li, N, et al., & Shi, Y (2013). Oral topotecan: Bioavailability, pharmacokinetics and impact of ABCG2 genotyping in Chinese patients with advanced cancers. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 67(8) 801–806. DOI:10.1016/j.biopha.2013.08.002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24074809
Léger, F, et al., & Chatelut, E (2004). Factors affecting pharmacokinetic variability of oral topotecan: a population analysis. British journal of cancer 90(2) 343–347. DOI:10.1038/sj.bjc.6601469 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14735174