.Pharmacolibrary.Drugs.ATC.L.L01DA01 .Pharmacolibrary.Drugs.ATC.L.L01DA01| name: | Dactinomycin |
| ATC code: | L01DA01 | route: | intravenous |
| n-compartments | 2 |
Dactinomycin (also known as actinomycin D) is a cytotoxic antibiotic used mainly as an antineoplastic agent. It is approved for use in the treatment of various cancers, including Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, and gestational trophoblastic neoplasia. It works by binding to DNA and inhibiting RNA synthesis, thus preventing cell replication.
Pharmacokinetic parameters reported in adult cancer patients following intravenous bolus administration. Data primarily from clinical studies in adult and paediatric patient populations with various solid tumors.
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