.Pharmacolibrary.Drugs.ATC.L.L01EF01 .Pharmacolibrary.Drugs.ATC.L.L01EF01| name: | Palbociclib |
| ATC code: | L01EF01 | route: | oral |
| n-compartments | 2 |
Palbociclib is an oral, selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), used primarily in the treatment of hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. It is an FDA- and EMA-approved antineoplastic agent administered in combination with endocrine therapy.
Population pharmacokinetics in adult advanced breast cancer patients, both female and male (predominantly female), mean age ~57 years, oral dosing.
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Yu, Y, et al., & Wang, D (2020). Palbociclib (PD-0332991) pharmacokinetics in subjects with impaired renal function. Cancer chemotherapy and pharmacology 86(6) 701–710. DOI:10.1007/s00280-020-04163-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33037918
Panetta, JC, et al., & Stewart, CF (2024). Population Pharmacokinetic and Pharmacodynamic Study of Palbociclib in Children and Young Adults with Recurrent, Progressive, or Refractory Brain Tumors. Pharmaceutics 16(12) –. DOI:10.3390/pharmaceutics16121528 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39771507