.Pharmacolibrary.Drugs.ATC.L.L01XA01

Information

name:Cisplatin
ATC code:L01XA01
route:intravenous
n-compartments2

Cisplatin is a platinum-based chemotherapy drug used principally in the treatment of various cancers including testicular, ovarian, bladder, and lung cancers. It acts by forming DNA crosslinks that inhibit DNA repair and replication, ultimately leading to cell death. Cisplatin is FDA approved and is widely used as a standard treatment option in oncology.

Pharmacokinetics

Pharmacokinetic parameters reported for adult cancer patients receiving cisplatin via intravenous infusion.

References

  1. de Jongh, FE, et al., & Sparreboom, A (2004). Population pharmacokinetics of cisplatin in adult cancer patients. Cancer chemotherapy and pharmacology 54(2) 105–112. DOI:10.1007/s00280-004-0790-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15127229

  2. Ozols, RF, et al., & Baergen, R (2003). Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 21(17) 3194–3200. DOI:10.1200/JCO.2003.02.153 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12860964

  3. Terranova, N, et al., & Hendriks, BS (2021). Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types. Cancer chemotherapy and pharmacology 87(2) 185–196. DOI:10.1007/s00280-020-04184-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/33145616

Revisions


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