.Pharmacolibrary.Drugs.ATC.L.L01XK01 .Pharmacolibrary.Drugs.ATC.L.L01XK01| name: | Olaparib |
| ATC code: | L01XK01 | route: | oral |
| n-compartments | 2 |
Olaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor used in the treatment of certain types of cancers, including ovarian, breast, pancreatic, and prostate cancers with BRCA mutations. It is approved for use in multiple countries, including the US and EU.
Pharmacokinetic parameters reported in adult cancer patients, both sexes, after oral administration of olaparib 300 mg (tablet formulation) twice daily.
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Dong, R, et al., & Zhang, X (2024). Evaluation of Olaparib Tablet Safety and Pharmacokinetics in Healthy Chinese Male Subjects. Drug design, development and therapy 18 5529–5539. DOI:10.2147/DDDT.S481481 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39650853
Bundred, N, et al., & Dixon, JM (2013). Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a phase I multicentre trial in patients scheduled for elective breast cancer surgery. Investigational new drugs 31(4) 949–958. DOI:10.1007/s10637-012-9922-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23315029