name: | Flutamide | |
ATC code: | L02BB01 | route: | oral |
compartments: | 1 | |
dosage: | 250 | mg |
volume of distribution: | 100 | L |
clearance: | 1100 | mL/min |
other parameters in model implementation |
Flutamide is a nonsteroidal antiandrogen formerly used in the treatment of prostate cancer and sometimes used off-label for other androgen-dependent conditions. It acts by inhibiting the action of androgens at the androgen receptor. Flutamide has largely been replaced by newer agents due to hepatotoxicity concerns and is not a first-line therapy today.
Pharmacokinetic parameters reported for healthy adult male volunteers under fasting conditions.