.Pharmacolibrary.Drugs.ATC.L.L04AB06

Information

Golimumab is a fully human monoclonal antibody that targets and neutralizes tumor necrosis factor alpha (TNF-α), a cytokine involved in systemic inflammation. It is approved and used for the treatment of autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis.

Pharmacokinetics

Pharmacokinetic parameters derived from healthy and patient populations (including adults with rheumatoid arthritis), both male and female, aged between 18 and 80 years. Parameters are for subcutaneous administration as per typical therapeutic protocols.

References

1. Hyams, JS, et al., & Strauss, R (2017). Subcutaneous Golimumab in Pediatric Ulcerative Colitis: Pharmacokinetics and Clinical Benefit. Inflammatory bowel diseases 23(12) 2227–2237. DOI:10.1097/MIB.0000000000001262 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29140944

2. Adedokun, OJ, et al., & Sandborn, WJ (2020). Population Pharmacokinetics and Exposure-Response Modeling of Golimumab in Adults With Moderately to Severely Active Ulcerative Colitis. Clinical therapeutics 42(1) 157–174.e4. DOI:10.1016/j.clinthera.2019.11.010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31982148

3. Xu, Y, et al., & Zhou, H (2019). Population Pharmacokinetics and Exposure-Response Modeling Analyses of Golimumab in Children With Moderately to Severely Active Ulcerative Colitis. Journal of clinical pharmacology 59(4) 590–604. DOI:10.1002/jcph.1353 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30536638

Revisions

• 06/2025 initial generated model