.Pharmacolibrary.Drugs.ATC.L.L04AF02 .Pharmacolibrary.Drugs.ATC.L.L04AF02| name: | Baricitinib |
| ATC code: | L04AF02 | route: | oral |
| n-compartments | 2 |
Baricitinib is an orally administered, selective inhibitor of Janus kinase (JAK)1 and JAK2, used primarily for the treatment of moderate to severe rheumatoid arthritis in adults, and is also approved for use in some cases of COVID-19. It is currently approved by the FDA and EMA for these indications.
Pharmacokinetic profile based on studies of healthy adult volunteers (both sexes, typical age 18-55 years, normal renal and hepatic function) after single oral dose administration.
Ramanan, AV, et al., & Ruperto, N (2023). Baricitinib in juvenile idiopathic arthritis: an international, phase 3, randomised, double-blind, placebo-controlled, withdrawal, efficacy, and safety trial. Lancet (London, England) 402(10401) 555–570. DOI:10.1016/S0140-6736(23)00921-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37423231
Kim, H, et al., & Goldbach-Mansky, R (2018). Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients. Clinical pharmacology and therapeutics 104(2) 364–373. DOI:10.1002/cpt.936 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29134648
Zhao, X, et al., & Cui, YM (2020). Pharmacokinetics, Safety, and Tolerability of Single- and Multiple-Dose Once-Daily Baricitinib in Healthy Chinese Subjects: A Randomized Placebo-Controlled Study. Clinical pharmacology in drug development 9(8) 952–960. DOI:10.1002/cpdd.868 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32945153