.Pharmacolibrary.Drugs.ATC.L.L04AK02 .Pharmacolibrary.Drugs.ATC.L.L04AK02| name: | Teriflunomide |
| ATC code: | L04AK02 | route: | oral |
| n-compartments | 2 |
Teriflunomide is an oral immunomodulatory drug approved for the treatment of relapsing forms of multiple sclerosis (MS). It works by inhibiting the enzyme dihydroorotate dehydrogenase, thus interfering with de novo pyrimidine synthesis in rapidly dividing cells such as activated lymphocytes.
Population pharmacokinetics in adult patients with multiple sclerosis, both sexes, typical dose, without significant comorbidities.
Kruger, TM, et al., & Ruixo, JJP (2023). Clinical Pharmacokinetics of Ponesimod, a Selective S1P1 Receptor Modulator, in the Treatment of Multiple Sclerosis. Clinical pharmacokinetics 62(11) 1533–1550. DOI:10.1007/s40262-023-01308-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37776485
Shin, Y, et al., & Park, K (2023). Development of a population pharmacokinetic model and optimal dosing regimen of leflunomide in Korean population. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 184 106402–None. DOI:10.1016/j.ejps.2023.106402 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36754259
Agarwal, S, et al., & Pal, TK (2012). Comparative bioequivalence study of leflunomide tablets in Indian healthy volunteers. Arzneimittel-Forschung 62(3) 145–148. DOI:10.1055/s-0031-1298024 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22278631