.Pharmacolibrary.Drugs.ATC.L.L04AX01

Information

Azathioprine is an immunosuppressive antimetabolite used to prevent organ transplant rejection and to treat autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. It is an approved drug still in clinical use.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects after a single oral dose.

References

1. Rosenbaum, SE, et al., & Akhlaghi, F (2005). Population pharmacokinetics of cyclosporine in cardiopulmonary transplant recipients. Therapeutic drug monitoring 27(2) 116–122. DOI:10.1097/01.ftd.0000148448.51225.2c PUBMED:https://pubmed.ncbi.nlm.nih.gov/15795639

2. Ettenger, RB, & Grimm, EM (2001). Safety and efficacy of TOR inhibitors in pediatric renal transplant recipients. American journal of kidney diseases : the official journal of the National Kidney Foundation 38(4 Suppl 2) S22–S28. DOI:10.1053/ajkd.2001.27838 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11583941

3. Dirks, NL, et al., & Meibohm, B (2004). Pharmacokinetics of immunosuppressants: a perspective on ethnic differences. International journal of clinical pharmacology and therapeutics 42(12) 701–718. DOI:10.5414/cpp42701 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15624287

Revisions

• 06/2025 initial generated model