.Pharmacolibrary.Drugs.ATC.L.L04AX04

Information

name:Lenalidomide
ATC code:L04AX04
route:oral
n-compartments1

Lenalidomide is an immunomodulatory drug used primarily for the treatment of multiple myeloma and certain myelodysplastic syndromes. It is an oral derivative of thalidomide and is currently approved for use in several countries for these indications.

Pharmacokinetics

Pharmacokinetic parameters observed in adult patients (both sexes) with multiple myeloma after a single oral dose under fasting conditions.

References

  1. Hughes, JH, et al., & Foster, DJR (2019). Population pharmacokinetics of lenalidomide in patients with B-cell malignancies. British journal of clinical pharmacology 85(5) 924–934. DOI:10.1111/bcp.13873 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30672004

  2. Chen, N, et al., & Palmisano, M (2017). Clinical Pharmacokinetics and Pharmacodynamics of Lenalidomide. Clinical pharmacokinetics 56(2) 139–152. DOI:10.1007/s40262-016-0432-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27351179

  3. O'Donnell, EK, et al., & Raje, NS (2018). A phase 2 study of modified lenalidomide, bortezomib and dexamethasone in transplant-ineligible multiple myeloma. British journal of haematology 182(2) 222–230. DOI:10.1111/bjh.15261 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29740809

Revisions

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