.Pharmacolibrary.Drugs.ATC.M.M01AB05

Information

name:Diclofenac
ATC code:M01AB05
route:oral
n-compartments2

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory disorders such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is also used for acute pain management and dysmenorrhea. Diclofenac is widely approved and is used both orally and topically.

Pharmacokinetics

Healthy adult volunteers, single oral dose, typical PK analysis.

References

  1. Moore, RA, et al., & Straube, S (2015). Effects of food on pharmacokinetics of immediate release oral formulations of aspirin, dipyrone, paracetamol and NSAIDs - a systematic review. British journal of clinical pharmacology 80(3) 381–388. DOI:10.1111/bcp.12628 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25784216

  2. Standing, JF, et al., & Wong, IC (2008). Population pharmacokinetics of oral diclofenac for acute pain in children. British journal of clinical pharmacology 66(6) 846–853. DOI:10.1111/j.1365-2125.2008.03289.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/19032726

  3. Lötsch, J, et al., & Kobal, G (2000). Population pharmacokinetics of fast release oral diclofenac in healthy volunteers: relation to pharmacodynamics in an experimental pain model. Pharmaceutical research 17(1) 77–84. DOI:10.1023/a:1007574710140 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10714612

Revisions


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