.Pharmacolibrary.Drugs.ATC.M.M01AB05_1

Information

name:Diclofenac_1
ATC code:M01AB05_1
route:intravenous
n-compartments2

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory disorders such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is also used for acute pain management and dysmenorrhea. Diclofenac is widely approved and is used both orally and topically.

Pharmacokinetics

Healthy adult volunteers, single intravenous injection, typical PK parameter estimates.

References

  1. Huntjens, DR, et al., & Della Pasqua, O (2008). Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats. British journal of pharmacology 153(5) 1072–1084. DOI:10.1038/sj.bjp.0707643 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18193075

  2. Standing, JF, et al., & Olkkola, KT (2011). Diclofenac pharmacokinetic meta-analysis and dose recommendations for surgical pain in children aged 1-12 years. Paediatric anaesthesia 21(3) 316–324. DOI:10.1111/j.1460-9592.2010.03509.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/21276131

  3. Goldwater, R, et al., & Carr, DB (2016). A Phase I study evaluating the effect of age and weight on the pharmacokinetics of an injectable formulation of diclofenac solubilized with hydroxypropyl-β-cyclodextrin. Clinical pharmacology : advances and applications 8 203–212. DOI:10.2147/CPAA.S98437 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28008289

Revisions


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