name: | Naproxen |
ATC code: | M01AE02 | route: | oral |
n-compartments | 2 |
Naproxen is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of pain, inflammation, and fever. It is commonly prescribed for conditions such as arthritis, muscle pain, back pain, menstrual cramps, and headaches. Naproxen is widely approved and in clinical use today.
Pharmacokinetic parameters reported in healthy adult subjects following oral administration.
Välitalo, P, et al., & Kokki, H (2012). Plasma and cerebrospinal fluid pharmacokinetics of naproxen in children. Journal of clinical pharmacology 52(10) 1516–1526. DOI:10.1177/0091270011418658 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22067196
Mendell, J, et al., & Samama, MM (2013). The effects of the antiplatelet agents, aspirin and naproxen, on pharmacokinetics and pharmacodynamics of the anticoagulant edoxaban, a direct factor Xa inhibitor. Journal of cardiovascular pharmacology 62(2) 212–221. DOI:10.1097/FJC.0b013e3182970991 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23615159
Kubitza, D, et al., & Zuehlsdorf, M (2007). Rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--has no clinically relevant interaction with naproxen. British journal of clinical pharmacology 63(4) 469–476. DOI:10.1111/j.1365-2125.2006.02776.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/17100983