.Pharmacolibrary.Drugs.ATC.M.M01AE02

Information

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of pain, inflammation, and fever. It is commonly prescribed for conditions such as arthritis, muscle pain, back pain, menstrual cramps, and headaches. Naproxen is widely approved and in clinical use today.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult subjects following oral administration.

References

1. Välitalo, P, et al., & Kokki, H (2012). Plasma and cerebrospinal fluid pharmacokinetics of naproxen in children. Journal of clinical pharmacology 52(10) 1516–1526. DOI:10.1177/0091270011418658 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22067196

2. Mendell, J, et al., & Samama, MM (2013). The effects of the antiplatelet agents, aspirin and naproxen, on pharmacokinetics and pharmacodynamics of the anticoagulant edoxaban, a direct factor Xa inhibitor. Journal of cardiovascular pharmacology 62(2) 212–221. DOI:10.1097/FJC.0b013e3182970991 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23615159

3. Kubitza, D, et al., & Zuehlsdorf, M (2007). Rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--has no clinically relevant interaction with naproxen. British journal of clinical pharmacology 63(4) 469–476. DOI:10.1111/j.1365-2125.2006.02776.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/17100983

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)