.Pharmacolibrary.Drugs.ATC.M.M01AE18

Information

name:Naproxcinod
ATC code:M01AE18
route:oral
compartments:1
dosage:750mg
volume of distribution:10L
clearance:0.15L/h
other parameters in model implementation

Naproxcinod is a nitric oxide-donating prodrug of naproxen, developed as an anti-inflammatory and analgesic agent for the treatment of osteoarthritis and other musculoskeletal disorders. It was investigated as a potentially safer NSAID, aiming to reduce gastrointestinal and cardiovascular side effects. As of now, naproxcinod is not approved for use in any major regulatory jurisdiction and remains an investigational compound.

Pharmacokinetics

No published human pharmacokinetic models are available; parameters provided below are coarse estimates based on analogies to naproxen and existing public reports on naproxcinod in healthy adult subjects after oral administration.

References

    Revisions


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