.Pharmacolibrary.Drugs.ATC.M.M02AA12

Information

name:Naproxen
ATC code:M02AA12
route:oral
n-compartments1

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, swelling, and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps. It is widely approved and in use globally.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects, mixed sex, single oral dose.

References

  1. Välitalo, P, et al., & Kokki, H (2012). Plasma and cerebrospinal fluid pharmacokinetics of naproxen in children. Journal of clinical pharmacology 52(10) 1516–1526. DOI:10.1177/0091270011418658 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22067196

  2. Mendell, J, et al., & Samama, MM (2013). The effects of the antiplatelet agents, aspirin and naproxen, on pharmacokinetics and pharmacodynamics of the anticoagulant edoxaban, a direct factor Xa inhibitor. Journal of cardiovascular pharmacology 62(2) 212–221. DOI:10.1097/FJC.0b013e3182970991 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23615159

  3. Kubitza, D, et al., & Zuehlsdorf, M (2007). Rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--has no clinically relevant interaction with naproxen. British journal of clinical pharmacology 63(4) 469–476. DOI:10.1111/j.1365-2125.2006.02776.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/17100983

Revisions


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