.Pharmacolibrary.Drugs.ATC.M.M02AA13

Information

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely used for its analgesic, antipyretic, and anti-inflammatory effects. It is commonly used for the treatment of mild to moderate pain, inflammation, and fever. Ibuprofen is an over-the-counter medication and is approved for clinical use worldwide.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after a single oral dose.

References

1. Moore, RA, et al., & Straube, S (2015). Effects of food on pharmacokinetics of immediate release oral formulations of aspirin, dipyrone, paracetamol and NSAIDs - a systematic review. British journal of clinical pharmacology 80(3) 381–388. DOI:10.1111/bcp.12628 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25784216

2. Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834

3. Sharma, PK, et al., & Narang, A (2003). Pharmacokinetics of oral ibuprofen in premature infants. Journal of clinical pharmacology 43(9) 968–973. DOI:10.1177/0091270003254635 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12971028

Revisions

• 06/2025 initial generated model