.Pharmacolibrary.Drugs.ATC.M.M02AA19

Information

Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) belonging to the phenylalkanoic acid derivative class, known for its analgesic, anti-inflammatory, and antipyretic activities. It is primarily used for the symptomatic treatment of pain and inflammation in musculoskeletal disorders and is available in both oral and topical formulations. Flurbiprofen is approved and used in several countries for pain management.

Pharmacokinetics

PK parameters reported in healthy adult volunteers after single oral administration.

References

1. Qayyum, A, et al., & Farooqi, ZU (2011). Determination of pharmacokinetics of flurbiprofen in Pakistani population using modified HPLC method. Journal of chromatographic science 49(2) 108–113. DOI:10.1093/chrsci/49.2.108 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21223634

2. Lee, YJ, et al., & Lee, SY (2015). Effects of CYP2C9*1/*3 genotype on the pharmacokinetics of flurbiprofen in Korean subjects. Archives of pharmacal research 38(6) 1232–1237. DOI:10.1007/s12272-015-0580-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25712887

3. Kumpulainen, E, et al., & Kokki, H (2010). Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children. British journal of clinical pharmacology 70(4) 557–566. DOI:10.1111/j.1365-2125.2010.03720.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/20840447

Revisions

• 06/2025 initial generated model