.Pharmacolibrary.Drugs.ATC.M.M02AA21

Information

name:Tolmetin
ATC code:M02AA21
route:oral
n-compartments1

Tolmetin is a non-steroidal anti-inflammatory drug (NSAID) previously used for the treatment of pain and inflammation associated with conditions like rheumatoid arthritis and osteoarthritis. Its use has declined and is currently discontinued or unavailable in many markets due to safety concerns and availability of alternative NSAIDs.

Pharmacokinetics

Pharmacokinetic parameters estimated for healthy adult subjects after oral administration, as no direct publications for tolmetin with ATC code M02AA21 (topical) were identified. Values are extrapolated from available data on oral tolmetin, as topical/systemic PK data for M02AA21 are absent in the literature.

References

  1. Flores-Murrieta, FJ, et al., & Castañeda-Hernández, G (1998). Pharmacokinetic-pharmacodynamic modeling of tolmetin antinociceptive effect in the rat using an indirect response model: a population approach. Journal of pharmacokinetics and biopharmaceutics 26(5) 547–557. DOI:10.1023/a:1023273100270 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10205770

  2. Mandema, JW, & Stanski, DR (1996). Population pharmacodynamic model for ketorolac analgesia. Clinical pharmacology and therapeutics 60(6) 619–635. DOI:10.1016/S0009-9236(96)90210-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8988064

  3. Dupuis, LL, et al., & Laxer, RM (1990). Methotrexate-nonsteroidal antiinflammatory drug interaction in children with arthritis. The Journal of rheumatology 17(11) 1469–1473. PUBMED:https://pubmed.ncbi.nlm.nih.gov/2273487

Revisions


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