.Pharmacolibrary.Drugs.ATC.M.M02AA26

Information

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties, primarily used for the treatment of acute pain, symptomatic treatment of osteoarthritis, and primary dysmenorrhea. Its approval and clinical use have been restricted or withdrawn in several countries due to concerns regarding potential hepatotoxicity.

Pharmacokinetics

Pharmacokinetic parameters obtained from healthy adult volunteers after a single oral administration.

References

1. Hanif, M, et al., & Khan, SM (2017). PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION. Acta poloniae pharmaceutica 74(2) 489–495. PUBMED:https://pubmed.ncbi.nlm.nih.gov/29624254

2. Kim, MS, et al., & Kang, JS (2012). Quantification of nimesulide in human plasma by high-performance liquid chromatography with ultraviolet detector (HPLC-UV): application to pharmacokinetic studies in 28 healthy Korean subjects. Journal of chromatographic science 50(5) 396–400. DOI:10.1093/chromsci/bms014 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22451531

3. Galligan, TH, et al., & Naidoo, V (2022). The non-steroidal anti-inflammatory drug nimesulide kills Gyps vultures at concentrations found in the muscle of treated cattle. The Science of the total environment 807(Pt 2) 150788–None. DOI:10.1016/j.scitotenv.2021.150788 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34619222

Revisions

• 06/2025 initial generated model