.Pharmacolibrary.Drugs.ATC.M.M02AB01 .Pharmacolibrary.Drugs.ATC.M.M02AB01| name: | Capsaicin |
| ATC code: | M02AB01 | route: | topical |
| n-compartments | 1 |
Capsaicin is a naturally occurring compound derived from chili peppers, primarily used as a topical analgesic for the treatment of neuropathic pain, musculoskeletal pain, and arthritis. It acts by desensitizing sensory neurons and is commonly available in creams or patches. Capsaicin is approved for topical use in several regions, including the USA and EU.
Pharmacokinetic parameters estimated for topical administration in healthy adults; detailed PK data in humans are limited. Most data are from animal or in vitro studies.
Babbar, S, et al., & Bley, K (2009). Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain. Therapeutic drug monitoring 31(4) 502–510. DOI:10.1097/FTD.0b013e3181a8b200 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19494795
Kalliomäki, J, et al., & Simpson, DM (2013). Evaluation of a novel chemokine receptor 2 (CCR2)-antagonist in painful diabetic polyneuropathy. Scandinavian journal of pain 4(2) 77–83. DOI:10.1016/j.sjpain.2012.10.003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29913894