.Pharmacolibrary.Drugs.ATC.M.M03BA73

Information

name:MethocarbamolCombinationsWithPsycholeptics
ATC code:M03BA73
route:oral
compartments:1
dosage:1500mg
volume of distribution:36L
clearance:4.8L/h
other parameters in model implementation

Methocarbamol is a centrally acting muscle relaxant commonly used to relieve skeletal muscle spasms and pain associated with musculoskeletal conditions. Combinations with psycholeptics (tranquilizers, sedatives, antipsychotics) have been utilized in the past to enhance the muscle relaxant and sedative effect for short-term musculoskeletal therapy; however, such combinations are largely historical and are not widely approved in current therapeutic guidelines due to safety concerns.

Pharmacokinetics

Pharmacokinetic parameters are estimated based on data for methocarbamol monotherapy in healthy adult populations, as there is a lack of direct published PK data specifically for its combinations with psycholeptics.

References

    Revisions


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