.Pharmacolibrary.Drugs.ATC.M.M03BB03

Information

name:Chlorzoxazone
ATC code:M03BB03
route:oral
n-compartments1

Chlorzoxazone is a centrally acting muscle relaxant used to relieve pain and discomfort caused by muscle spasms. It is often prescribed in combination with other treatments for musculoskeletal conditions. While once commonly used, its presence on the market has diminished in some countries due to concerns over hepatotoxicity, but it is still approved and marketed in several regions.

Pharmacokinetics

Pharmacokinetics reported in healthy adult volunteers, both male and female.

References

  1. de Vries, JD, et al., & Hoener, BA (1994). Variability in the disposition of chlorzoxazone. Biopharmaceutics & drug disposition 15(7) 587–597. DOI:10.1002/bdd.2510150706 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7849234

  2. Li, L, & Zhang, Y (1998). [Determination of chlorzoxazone and its metabolite 6-hydroxychlorzoxazone in plasma by HPLC and their pharmacokinetics]. Yao xue xue bao = Acta pharmaceutica Sinica 33(10) 731–736. PUBMED:https://pubmed.ncbi.nlm.nih.gov/12016924

  3. Raucy, JL, et al., & Carpenter, SP (1999). CYP2E1 expression in human lymphocytes from various ethnic populations. Alcoholism, clinical and experimental research 23(12) 1868–1874. PUBMED:https://pubmed.ncbi.nlm.nih.gov/10630604

Revisions


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