.Pharmacolibrary.Drugs.ATC.M.M03BX02 .Pharmacolibrary.Drugs.ATC.M.M03BX02| name: | Tizanidine |
| ATC code: | M03BX02 | route: | oral |
| n-compartments | 1 |
Tizanidine is a centrally acting alpha-2 adrenergic agonist used as a muscle relaxant to manage spasticity associated with conditions like multiple sclerosis and spinal cord injury. It is approved for clinical use in various countries, including the US and Europe.
Pharmacokinetic parameters reported in healthy adult subjects after single oral dose.
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Zhang, M, et al., & Jamei, M (2022). Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework. Drug metabolism and disposition: the biological fate of chemicals 50(7) 957–967. DOI:10.1124/dmd.121.000818 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35504655