.Pharmacolibrary.Drugs.ATC.M.M04AA01

Information

name:Allopurinol
ATC code:M04AA01
route:oral
n-compartments1

Allopurinol is a xanthine oxidase inhibitor used primarily to decrease high blood uric acid levels, commonly used in the management of chronic gout and to prevent uric acid nephropathy during cancer chemotherapy. It is approved and widely used in clinical practice today.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers (both male and female) after a single oral dose, fasted state.

References

  1. Vora, B, et al., & Giacomini, KM (2021). Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics. Clinical and translational science 14(4) 1431–1443. DOI:10.1111/cts.12992 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33931953

  2. Liu, Z, et al., & Guo, R (2015). CGRP mediate the isosorbide-5-mononitrate cardiovascular response in healthy Chinese male volunteers through a XOR-independent pathway. International journal of clinical pharmacology and therapeutics 53(4) 325–334. DOI:10.5414/CP202178 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25740261

  3. Takada, M, et al., & Shibakawa, M (2005). Appropriate dosing regimen of allopurinol in Japanese patients. Journal of clinical pharmacy and therapeutics 30(4) 407–412. DOI:10.1111/j.1365-2710.2005.00670.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/15985055

Revisions


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