.Pharmacolibrary.Drugs.ATC.M.M04AC01

Information

name:Colchicine
ATC code:M04AC01
route:oral
n-compartments2

Colchicine is an alkaloid medication that inhibits microtubule polymerization, primarily used for the treatment and prevention of gout flares and familial Mediterranean fever. It is also occasionally used for other inflammatory conditions. Colchicine is an approved drug and remains widely used today.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after single oral dose administration.

References

  1. Terkeltaub, RA, et al., & Davis, MW (2010). High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study. Arthritis and rheumatism 62(4) 1060–1068. DOI:10.1002/art.27327 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20131255

  2. Mutoh, A, et al., & Ueda, S (2023). Pharmacokinetics of low doses of colchicine in the leukocytes of Japanese healthy individuals. Translational and clinical pharmacology 31(4) 217–225. DOI:10.12793/tcp.2023.31.e19 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38196999

  3. Ford, JL, et al., & Gonzalez, D (2022). Physiologically Based Pharmacokinetic Modeling of Metformin in Children and Adolescents With Obesity. Journal of clinical pharmacology 62(8) 960–969. DOI:10.1002/jcph.2034 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35119103

Revisions


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