.Pharmacolibrary.Drugs.ATC.M.M05BA01

Information

name:EtidronicAcid
ATC code:M05BA01
route:oral
n-compartments1

Etidronic acid is a bisphosphonate drug that inhibits bone resorption, commonly used for the treatment of osteoporosis, Paget's disease of bone, and hypercalcemia of malignancy. It was one of the first bisphosphonates developed and is now less commonly used, having been largely replaced by newer bisphosphonates.

Pharmacokinetics

Pharmacokinetic parameters estimated for healthy adult subjects based on available pharmacological profiles and regulatory documents. No direct PK model or clinical PK parameterization with numerical values published in peer-reviewed literature.

References

  1. Mitchell, DY, et al., & Powell, JH (2000). Effect of renal function on risedronate pharmacokinetics after a single oral dose. British journal of clinical pharmacology 49(3) 215–222. DOI:10.1046/j.1365-2125.2000.00135.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/10718776

  2. Ogura, Y, et al., & Orimo, H (2004). Clinical trial of risedronate in Japanese volunteers: single and multiple oral dose studies. Journal of bone and mineral metabolism 22(2) 111–119. DOI:10.1007/s00774-003-0458-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/14999521

  3. Denk, E, et al., & Walczyk, T (2007). Evaluation of 41calcium as a new approach to assess changes in bone metabolism: effect of a bisphosphonate intervention in postmenopausal women with low bone mass. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 22(10) 1518–1525. DOI:10.1359/jbmr.070617 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17576167

Revisions


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