.Pharmacolibrary.Drugs.ATC.M.M05BX04 .Pharmacolibrary.Drugs.ATC.M.M05BX04| name: | Denosumab |
| ATC code: | M05BX04 | route: | subcutaneous |
| n-compartments | 2 |
Denosumab is a fully human monoclonal antibody that inhibits RANK ligand (RANKL), a key mediator of osteoclast formation, function, and survival, thus reducing bone resorption and increasing bone mass. It is approved for the treatment of osteoporosis in postmenopausal women and men at increased risk of fractures, as well as for bone loss associated with certain cancers and for prevention of skeletal-related events in patients with bone metastases.
Pharmacokinetic parameters reported for adults (including postmenopausal women with osteoporosis) after subcutaneous administration of denosumab 60 mg.
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