.Pharmacolibrary.Drugs.ATC.N.N01AB05

Information

Trichloroethylene is a volatile chlorinated organic solvent that has been used historically as an inhalation anesthetic and analgesic agent but is now primarily employed in industrial applications as a degreasing solvent. Due to concerns about toxicity, carcinogenicity, and safer alternatives, medical use in anesthesia has been discontinued in most countries.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult human volunteers following single inhalation exposure.

References

1. Waters, EM, et al., & Huff, JE (1977). Trichloroethylene. I. An overview. Journal of toxicology and environmental health 2(3) 671–707. DOI:10.1080/15287397709529469 PUBMED:https://pubmed.ncbi.nlm.nih.gov/403297

2. Rouhou, MC, et al., & Haddad, S (2015). In vivo effects of naproxen, salicylic acid, and valproic acid on the pharmacokinetics of trichloroethylene and metabolites in rats. Journal of toxicology and environmental health. Part A 78(11) 671–684. DOI:10.1080/15287394.2015.1020977 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26039745

3. Sohn, MD, et al., & Blancato, JN (2004). Reconstructing population exposures from dose biomarkers: inhalation of trichloroethylene (TCE) as a case study. Journal of exposure analysis and environmental epidemiology 14(3) 204–213. DOI:10.1038/sj.jea.7500314 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15141149

Revisions

• 06/2025 initial generated model