.Pharmacolibrary.Drugs.ATC.N.N01AB07

Information

Desflurane is a volatile halogenated ether anesthetic used for induction and maintenance of general anesthesia. It is characterized by its rapid onset and offset due to low blood-gas partition coefficient. Desflurane is approved and widely used today in both inpatient and outpatient surgical settings.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult surgical patients, both sexes, undergoing general anesthesia.

References

1. Esper, T, et al., & Rueffert, H (2015). Blood/Gas partition coefficients for isoflurane, sevoflurane, and desflurane in a clinically relevant patient population. Anesthesia and analgesia 120(1) 45–50. DOI:10.1213/ANE.0000000000000516 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25393590

2. Lemmens, HJ (2010). Perioperative pharmacology in morbid obesity. Current opinion in anaesthesiology 23(4) 485–491. DOI:10.1097/ACO.0b013e32833b0a8c PUBMED:https://pubmed.ncbi.nlm.nih.gov/20531173

3. Casati, A, & Putzu, M (2005). Anesthesia in the obese patient: pharmacokinetic considerations. Journal of clinical anesthesia 17(2) 134–145. DOI:10.1016/j.jclinane.2004.01.009 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15809132

Revisions

• 06/2025 initial generated model