.Pharmacolibrary.Drugs.ATC.N.N01AB08

Information

name:Sevoflurane
ATC code:N01AB08
route:inhalational
n-compartments2

Sevoflurane is a volatile, non-flammable inhalational anesthetic agent used for the induction and maintenance of general anesthesia in both adults and pediatric patients. It is widely approved and commonly used in clinical anesthesia practice due to its low blood/gas partition coefficient, allowing for rapid induction and recovery.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers, post steady-state inhalational administration.

References

  1. Dholakia, U, et al., & Pypendop, BH (2020). Pharmacokinetics of midazolam in sevoflurane-anesthetized cats. Veterinary anaesthesia and analgesia 47(2) 200–209. DOI:10.1016/j.vaa.2019.11.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31983556

  2. Cortínez, LI, & Anderson, BJ (2018). Modeling the pharmacokinetics and pharmacodynamics of sevoflurane using compartment models in children and adults. Paediatric anaesthesia 28(10) 834–840. DOI:10.1111/pan.13465 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30117213

  3. Enlund, M, et al., & Meineke, I (2008). Population pharmacokinetics of sevoflurane in conjunction with the AnaConDa: toward target-controlled infusion of volatiles into the breathing system. Acta anaesthesiologica Scandinavica 52(4) 553–560. DOI:10.1111/j.1399-6576.2008.01579.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/18339161

Revisions


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