name: | Sevoflurane |
ATC code: | N01AB08 | route: | inhalational |
n-compartments | 2 |
Sevoflurane is a volatile, non-flammable inhalational anesthetic agent used for the induction and maintenance of general anesthesia in both adults and pediatric patients. It is widely approved and commonly used in clinical anesthesia practice due to its low blood/gas partition coefficient, allowing for rapid induction and recovery.
Pharmacokinetic parameters reported in healthy adult volunteers, post steady-state inhalational administration.
Dholakia, U, et al., & Pypendop, BH (2020). Pharmacokinetics of midazolam in sevoflurane-anesthetized cats. Veterinary anaesthesia and analgesia 47(2) 200–209. DOI:10.1016/j.vaa.2019.11.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31983556
Cortínez, LI, & Anderson, BJ (2018). Modeling the pharmacokinetics and pharmacodynamics of sevoflurane using compartment models in children and adults. Paediatric anaesthesia 28(10) 834–840. DOI:10.1111/pan.13465 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30117213
Enlund, M, et al., & Meineke, I (2008). Population pharmacokinetics of sevoflurane in conjunction with the AnaConDa: toward target-controlled infusion of volatiles into the breathing system. Acta anaesthesiologica Scandinavica 52(4) 553–560. DOI:10.1111/j.1399-6576.2008.01579.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/18339161