.Pharmacolibrary.Drugs.ATC.N.N01AH01

Information

Fentanyl is a potent synthetic opioid analgesic, primarily used in anesthesia and for managing severe pain. It acts mainly as a μ-opioid receptor agonist, providing profound analgesia and sedation. Fentanyl is approved and widely used today both in acute settings (e.g., perioperative, ICU) and for chronic pain, often as transdermal patches or intravenous injections.

Pharmacokinetics

Healthy adult volunteers, both sexes, aged approx. 20-40 years, after single intravenous dose.

References

1. Ziesenitz, VC, et al., & van den Anker, JN (2018). Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review. Clinical pharmacokinetics 57(2) 125–149. DOI:10.1007/s40262-017-0569-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28688027

2. Smith, HAB, et al., & Berkenbosch, JW (2022). 2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 23(2) e74–e110. DOI:10.1097/PCC.0000000000002873 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35119438

3. Saari, TI, et al., & Dale, O (2024). Clinical Pharmacokinetics and Pharmacodynamics of Naloxone. Clinical pharmacokinetics 63(4) 397–422. DOI:10.1007/s40262-024-01355-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38485851

Revisions

• 06/2025 initial generated model