.Pharmacolibrary.Drugs.ATC.N.N01AX03

Information

Ketamine is a dissociative anesthetic primarily used for anesthesia and analgesia. It acts as an NMDA receptor antagonist and is notable for its use in both human and veterinary medicine. Ketamine has also been researched and used off-label for treatment-resistant depression and acute pain management. It is approved and in clinical use as an anesthetic agent.

Pharmacokinetics

Pharmacokinetic parameters of ketamine in healthy adult volunteers following intravenous administration.

References

1. Hornik, CP, et al., & Lee, JH (2018). Population Pharmacokinetics of Intramuscular and Intravenous Ketamine in Children. Journal of clinical pharmacology 58(8) 1092–1104. DOI:10.1002/jcph.1116 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29677389

2. Fanta, S, et al., & Kalso, E (2015). Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing. European journal of clinical pharmacology 71(4) 441–447. DOI:10.1007/s00228-015-1826-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/25724645

3. Simons, P, et al., & Dahan, A (2022). . Frontiers in pain research (Lausanne, Switzerland) 3 946486–None. DOI:10.3389/fpain.2022.946486 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35899184

Revisions

• 06/2025 initial generated model