.Pharmacolibrary.Drugs.ATC.N.N01AX03_1

Information

name:Ketamine_1
ATC code:N01AX03_1
route:oral
n-compartments2

Ketamine is a dissociative anesthetic primarily used for anesthesia and analgesia. It acts as an NMDA receptor antagonist and is notable for its use in both human and veterinary medicine. Ketamine has also been researched and used off-label for treatment-resistant depression and acute pain management. It is approved and in clinical use as an anesthetic agent.

Pharmacokinetics

Pharmacokinetic parameters of ketamine after oral administration in healthy adult volunteers.

References

  1. Simons, P, et al., & Dahan, A (2022). . Frontiers in pain research (Lausanne, Switzerland) 3 946486–None. DOI:10.3389/fpain.2022.946486 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35899184

  2. Fanta, S, et al., & Kalso, E (2015). Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing. European journal of clinical pharmacology 71(4) 441–447. DOI:10.1007/s00228-015-1826-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/25724645

  3. Dutton, M, et al., & Hermens, DF (2023). Oral ketamine may offer a solution to the ketamine conundrum. Psychopharmacology 240(12) 2483–2497. DOI:10.1007/s00213-023-06480-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/37882811

Revisions


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