.Pharmacolibrary.Drugs.ATC.N.N01AX05 .Pharmacolibrary.Drugs.ATC.N.N01AX05| name: | Alfaxalone |
| ATC code: | N01AX05 | route: | intravenous |
| n-compartments | 2 |
Alfaxalone is a neuroactive steroid used as an intravenous anesthetic and sedative, primarily in veterinary medicine for induction and maintenance of anesthesia in dogs and cats. It enhances inhibitory neurotransmission mediated by GABA-A receptors. Not approved for human use; it is used due to its rapid onset, short duration, and favorable safety profile in animals.
Pharmacokinetic parameters from healthy adult female cats after single intravenous bolus of alfaxalone at a dose of 5 mg/kg.
Pypendop, BH, et al., & Pasloske, K (2018). Pharmacokinetics of alfaxalone infusions, context-sensitive half-time and recovery times in male neutered cats. Veterinary anaesthesia and analgesia 45(5) 630–639. DOI:10.1016/j.vaa.2018.06.003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30057008
Pypendop, BH, et al., & Pasloske, K (2018). Effective plasma alfaxalone concentration to produce immobility in male neutered cats. Veterinary anaesthesia and analgesia 45(3) 269–277. DOI:10.1016/j.vaa.2017.10.006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29415861